Drug overdose deaths are the leading cause of death among people under the switch to heroin because it is cheaper and easier to obtain. US deaths from drug overdose increased 54% from to , a new report by the CDC shows. Although rankings changed, the top 10 drugs. More Australians are accidentally overdosing on medicines than ever before. Taking too much of a medicine can be very dangerous, and even fatal. But accidental. Across the United States, 40 people die each day because of overdosing on narcotic prescription medications. The most commonly abused prescription drugs are. How can a fentanyl overdose be treated? As mentioned above, many drug dealers mix the cheaper fentanyl with other drugs like heroin. Many people who abuse painkillers switch to heroin for two reasons: It is cheaper and often easier to get. Because of naloxone's effectiveness. People can overdose on illicit drugs, alcohol, prescription medications, and many other substances. In many cases, overdoses are fatal. In the midst of this crisis, lethally potent street drugs are increasingly affordable and available, while their lifesaving antidote, naloxone. They also are aware of side effects and can watch patients closely for these. Which Drugs Are Abused? The most commonly used prescription drugs fall into three. Opioids—mainly synthetic opioids (other than methadone)—are currently the main driver of drug overdose deaths. % of opioid-involved overdose deaths involve.